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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Piperlongumine, Doxorubicin
Phytochemical Name Piperlongumine (PubChem CID: 637858 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 9
Ref_1
Pair Name Piperlongumine, Doxorubicin
Disease Info [ICD-11: 2B51] Osteosarcoma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Down-regulation Expression BIRC5 hsa332
Down-regulation Expression CDH2 hsa1000
Up-regulation Expression CDKN1A hsa1026
Down-regulation Expression CTNNB1 hsa1499
Down-regulation Expression FN1 hsa2335
Down-regulation Expression NFKB1 hsa4790
Up-regulation Expression ROS1 hsa6098
Up-regulation Expression SMAD4 hsa4089
Down-regulation Expression TNF hsa7124
Up-regulation Expression TP53 hsa7157
Down-regulation Expression TWIST1 hsa7291
In Vitro Model MG-63 Osteosarcoma Homo sapiens (Human) CVCL_0426
143B Osteosarcoma Homo sapiens (Human) CVCL_2270
KHOS/NP Osteosarcoma Homo sapiens (Human) CVCL_2546
Result Piperlongumine induces ROS mediated apoptosis by transcriptional regulation of SMAD4/P21/P53 genes and synergizes with doxorubicin in osteosarcoma cells
03. Reference
No. Title Href
1 Piperlongumine induces ROS mediated apoptosis by transcriptional regulation of SMAD4/P21/P53 genes and synergizes with doxorubicin in osteosarcoma cells. Chem Biol Interact. 2022 Feb 25;354:109832. doi: 10.1016/j.cbi.2022.109832. Click
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