TOP
Nav Bar
  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Piperlongumine, Doxorubicin
Phytochemical Name Piperlongumine (PubChem CID: 637858 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
Phytochemical		 2D-img
Download
2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
Download
2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
Hide/Show
Enhancing Drug Efficacy
Hide/Show
Combination Pair ID: 9
Ref_1
Pair Name Piperlongumine, Doxorubicin
Disease Info [ICD-11: 2B51] Osteosarcoma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Down-regulation Expression BCL2 hsa596
Down-regulation Expression BIRC5 hsa332
Up-regulation Expression BAX hsa581
Up-regulation Expression TP53 hsa7157
Up-regulation Expression CDKN1A hsa1026
Up-regulation Expression SMAD4 hsa4089
Down-regulation Expression TNF hsa7124
Down-regulation Expression NFKB1 hsa4790
Down-regulation Expression FN1 hsa2335
Down-regulation Expression CDH2 hsa1000
Down-regulation Expression CTNNB1 hsa1499
Down-regulation Expression TWIST1 hsa7291
Up-regulation Expression ROS1 hsa6098
In Vitro Model MG-63 Osteosarcoma Homo sapiens (Human) CVCL_0426
143B Osteosarcoma Homo sapiens (Human) CVCL_2270
KHOS/NP Osteosarcoma Homo sapiens (Human) CVCL_2546
Result Piperlongumine induces ROS mediated apoptosis by transcriptional regulation of SMAD4/P21/P53 genes and synergizes with doxorubicin in osteosarcoma cells
03. Reference
No. Title Href
1 Piperlongumine induces ROS mediated apoptosis by transcriptional regulation of SMAD4/P21/P53 genes and synergizes with doxorubicin in osteosarcoma cells. Chem Biol Interact. 2022 Feb 25;354:109832. doi: 10.1016/j.cbi.2022.109832. Click
It has been 419600 visits since 2024.08
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang
TOP